Gianfranco Balboni Selected Research

2',6'- dimethyltyrosyl- 1,2,3,4- tetrahydroisoquinolinecarbonyl- phenylalanyl- (N(epsilon)- benzyloxycarbonyl)lysine

8/2005

From the potent and selective mu opioid receptor agonist H-Dmt-d-Arg-Phe-Lys-NH(2) to the potent delta antagonist H-Dmt-Tic-Phe-Lys(Z)-OH.

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Gianfranco Balboni Research Topics

Disease

10	Neoplasms (Cancer) 01/2020 - 04/2011
9	Hypoxia (Hypoxemia) 01/2022 - 07/2007
9	Tics (Tic) 08/2010 - 01/2002
8	Pain (Aches) 12/2021 - 06/2006
7	Inflammation (Inflammations) 12/2021 - 08/2009
5	Alzheimer Disease (Alzheimer's Disease) 11/2019 - 12/2014
4	Neuroinflammatory Diseases 09/2021 - 04/2019
4	Melanoma (Melanoma, Malignant) 04/2020 - 08/2018
3	Hyperalgesia 12/2021 - 01/2016
3	Neuralgia (Stump Neuralgia) 12/2021 - 02/2016
3	Ischemia 12/2016 - 07/2012
2	Painful Neuropathy 09/2021 - 11/2019
2	Parkinson Disease (Parkinson's Disease) 11/2020 - 01/2019
2	Hypersensitivity (Allergy) 04/2019 - 08/2009
2	Acute Erythroblastic Leukemia (Erythroleukemia) 01/2019 - 08/2018
2	Brain Hypoxia-Ischemia (Hypoxia Ischemia, Brain) 12/2016 - 11/2009
2	Brain Injuries (Brain Injury) 12/2016 - 04/2015
2	Acute Pain 02/2016 - 09/2015
1	Wounds and Injuries (Trauma) 01/2022
1	Osteoarthritis 12/2021
1	Alopecia (Baldness) 11/2021
1	Fetal Growth Retardation (Intrauterine Growth Retardation) 03/2021
1	Pre-Eclampsia (Preeclampsia) 03/2021
1	Mitochondrial Diseases (Mitochondrial Disease) 11/2020
1	Peripheral Nervous System Diseases (PNS Diseases) 04/2019
1	Diabetes Mellitus 01/2019
1	Proteostasis Deficiencies 01/2019
1	Chronic Pain 01/2019
1	Glaucoma 01/2018
1	Choriocarcinoma 11/2017
1	Carcinoma (Carcinomatosis) 04/2016
1	Leukemia L1210 04/2016
1	T-Cell Leukemia (Leukemia, T Cell) 04/2016
1	Brain Ischemia (Cerebral Ischemia) 01/2016

Drug/Important Bio-Agent (IBA)

9	Protein Isoforms (Isoforms)IBA 01/2020 - 08/2012
8	Opioid Receptors (Opioid Receptor)IBA 01/2022 - 06/2006
8	delta Opioid Receptors (delta Opioid Receptor)IBA 12/2021 - 12/2002
6	Opioid Analgesics (Opioids)IBA 01/2019 - 06/2006
6	Glucose (Dextrose)FDA LinkGeneric 12/2016 - 07/2007
6	Oxygen (Dioxygen)IBA 12/2016 - 07/2007
6	2',6'- dimethyltyrosyl- 1,2,3,4- tetrahydroisoquinoline- 3- carboxylic acidIBA 08/2010 - 12/2002
5	2',6'- dimethyltyrosyl- 1,2,3,4- tetrahydroisoquinoline- 3- carboxylic acid (1H- benzimidazol- 2- yl)(carboxymethyl)methylamideIBA 01/2022 - 07/2013
5	Proteins (Proteins, Gene)FDA Link 01/2021 - 08/2009
4	Freund's AdjuvantIBA 12/2021 - 08/2009
4	EnzymesIBA 01/2020 - 09/2015
4	Amyloid (Amyloid Fibrils)IBA 11/2019 - 12/2014
4	ChemokinesIBA 11/2019 - 08/2009
4	LigandsIBA 04/2011 - 01/2002
3	Analgesics (Analgesic Drugs)IBA 12/2021 - 09/2015
3	Pharmaceutical PreparationsIBA 01/2020 - 09/2015
3	CytokinesIBA 04/2019 - 01/2015
3	Peptides (Polypeptides)IBA 01/2016 - 08/2012
2	AntioxidantsIBA 12/2021 - 04/2020
2	Bortezomib (Velcade)FDA Link 09/2021 - 04/2019
2	Endocrine-Gland-Derived Vascular Endothelial Growth Factor (Vascular Endothelial Growth Factor, Endocrine Gland Derived)IBA 03/2021 - 11/2017
2	ZincIBA 01/2020 - 01/2020
2	PiperazineIBA 01/2020 - 09/2015
2	HydrazonesIBA 01/2019 - 08/2018
2	Carbonic Anhydrases (Carbonic Anhydrase)IBA 01/2018 - 04/2014
2	Amyloid beta-PeptidesIBA 01/2017 - 10/2015
2	SulfonamidesIBA 09/2015 - 04/2014
2	mu Opioid Receptors (mu Opioid Receptor)IBA 07/2007 - 07/2004
2	AcidsIBA 12/2002 - 01/2002
1	LipopolysaccharidesIBA 01/2022
1	Interleukin-4 (Interleukin 4)IBA 01/2022
1	phenylisothiocyanateIBA 12/2021
1	Transcription Factors (Transcription Factor)IBA 12/2021
1	Potassium Channels (Potassium Channel)IBA 12/2021
1	diallyl disulfide (diallyl disulphide)IBA 12/2021
1	Hydrogen Sulfide (Sulfide, Hydrogen)IBA 12/2021
1	Proteasome InhibitorsIBA 09/2021
1	Sucrose (Saccharose)IBA 09/2021
1	Interleukin-6 Receptors (Interleukin 6 Receptor)IBA 09/2021
1	poly(tetramethylene succinate-co-tetramethylene adipate)IBA 04/2020
1	SLC-0111IBA 01/2020
1	Urea (Carbamide)FDA LinkGeneric 01/2020
1	NitrogenIBA 01/2020
1	BenzimidazolesIBA 01/2020
1	BenzenesulfonamidesIBA 01/2020
1	piperidineIBA 01/2020
1	Chemokine ReceptorsIBA 11/2019
1	Vincristine (Oncovin)FDA LinkGeneric 11/2019
1	Mitogen-Activated Protein Kinase 3IBA 01/2019
1	Proto-Oncogene Proteins c-akt (Protein Kinase B)IBA 01/2019
1	Heme Oxygenase-1IBA 01/2019
1	Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)IBA 01/2019
1	Mitogen-Activated Protein KinasesIBA 01/2019
1	quinone (benzoquinone)IBA 01/2019
1	sulforaphaneIBA 01/2019
1	Phosphatidylinositols (Phosphatidylinositol)IBA 01/2019
1	JNK Mitogen-Activated Protein KinasesIBA 01/2019
1	Antidepressive Agents (Antidepressants)IBA 01/2019
1	NAD (NADH)IBA 01/2019
1	Oxidoreductases (Dehydrogenase)IBA 01/2019
1	NaphthoquinonesIBA 01/2019
1	Celecoxib (Celebrex)FDA Link 01/2018
1	imidazoleIBA 04/2016
1	Cytostatic AgentsIBA 04/2016
1	Formaldehyde (Formol)FDA Link 02/2016

Therapy/Procedure

5	Therapeutics 01/2019 - 04/2011